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Scientists discovered that people with type 2 diabetes have blunted incretin responses compared to people without diabetes

Significant comorbidity exists among these conditions, exemplified by the frequent co-occurrence of depression and ASD with epilepsy (277), the common comorbidity of depression with migraine (277), and the elevated prevalence of inflammatory bowel disease or irritable bowel syndrome among migraine patients (278)

Hence, when iron hemostasis is interrupted, excessive iron may injure proteins, lipids and DNA within mitochondria and reduce ATP production, leading to energy stress and ferroptosis (Fig