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Suvorova et al., 2009), they show no evidence of oxidative stress or replicative insufficiency (Stenvall et al., 2011)

In mice, smoke effects on villi and TJs integrity were associated with increased small intestine permeability [57] Nicotine plays a protective role in ulcerative colitis (UC) by modulating cholinergic pathways in immune cells and reducing their activation and cytokine expression [58], while in Chrons disease (CD) it increases intestinal permeability by interacting with claudin gene expression [59], leading to apoptosis in the follicle-associated epithelium [60] and change in the composition of the gut microbiota [61]

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