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Curcumin prevents HSC upregulation by suppressing the succinic acid/HIF-1 signaling cascade and reducing succinic acid accumulation by countering fatty acid oxidation (She et al., 2018)

Nat Chem Biol 14(7):730737

And avoid the stress of regulatory uncertainty.

(119) revealed that IFNs signalings stimulated the myeloid-derived IL-10 expression, presenting a novel avenue for enhancing the T-cell immunity in patients with chronic liver disorders