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Beyond generating ROS to induce ICD, more sophisticated structural designs can integrate multiple therapeutic modalities into a single COF platform, creating stronger synergistic effects to more effectively ignite the immune response

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(z3) a thick bulbous end displaying within a bulbous segment staining reminiscent of teardrop-shaped IOs in their non-septated state 52 , and (z4) stain-resistant spores at the disintegrating filament end

Further exploration of the specific mechanisms linking ferroptosis to disease progression will deepen our understanding of these significant diseases and provide new strategies for more precise prevention and treatment options for patients