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This slight increase then leads to an increase in inflammatory cytokines (TNF-alpha, IL-1 beta) in macrophages[ref] Endoplasmic Reticulum (ER) stress, protein misfolding: The endoplasmic reticulum (ER) is an organelle in cells where newly synthesized proteins are folded, lipids are synthesized, and calcium is stored

Tolerance and experience: Regular drinkers may develop a tolerance to alcohol, meaning they can consume larger amounts without experiencing the same level of impairment