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ROS can modulate the expression of miRNAs, which in turn regulate gene expression post-transcriptionally [172, 173]

10.1172/JCI61405 J Clin Invest

And the mean, median and maximum lifespans of male SOD1 G93A GPX4 mice (n = 15) were 166, 165, and 178 days respectively, while the mean, median and maximum lifespans of male SOD1 G93A GPX4 mice (n = 11) were 160, 162, and 170 days respectively