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Oxidative Stress and Muscle Damage In a hindlimb unloading model, increased oxidative stress significantly impairs the antioxidant capacity of skeletal muscles, elevating lipid peroxidation levels and making muscles more susceptible to damage and atrophy during prolonged unloading and reloading

It is also worth noting that since acetaminophen overdose or ingestion with alcohol can cause hepatotoxicity and death, well controlled clinical studies must be conducted to ensure the safety and efficiency of acetaminophen before its clinical application for off-label application