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Other mechanisms include increased insulin resistance induced by high-dose glucocorticoids that increases intra-portal insulin, decreases IGFBP-1 that increases free IGF-I, and direct glucocorticoid effects in increasing hepatic IGF-I synthesis and decreasing hepatic insulin clearance (105)

44 The release of zinc from the ER is likely mediated by ZIP7, as ZIP7 predominantly resides in the ER, and silencing ZIP using siRNA prevented the occurrence of the zinc wave

[DOI] [PubMed] [Google Scholar] 124.Rdiger HA

You should only increase your dose (titrate) when: You have successfully tolerated the current dose for at least 1-2 weeks