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IGF-1 Modulation: Activation leads to a downstream increase in Insulin-like Growth Factor 1 (IGF-1), a master regulator of cellular growth and repair

When we tested exopher levels in this strain, which is wild type ftt-2 at the endogenous genomic locus and harbors a second copy of P mec-7 FTT-2::mSc inserted via MiniMos single site insertion 45 ( i.e ., at least 2X ftt-2 gene dose), we quantitated significantly increased TN exopher levels (Supplementary Fig

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However, if feeling worse lasts more than a few days, this could be due to overmethylation, other gene variations such as an expressed CBS gene variation that may need to be supported before adding methylation support, or a sensitivity to the supplements, and the supplements should be discontinued