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ACE 2 is a transmembrane protein that contains an extracellular zinc binding domain and located at multiple sites like renal tubular epithelium, lung alveolar epithelial cells, arterial and venous endothelial cells etc 20,54,55

Variants of this gene are also involved in medication resistance to antiviral and anticancer drugs.[ref] The wet earwax allele was also associated with a higher risk of breast cancer in Japanese women but not in women of European descent.[ref][ref][ref] In Japanese men, carrying the allele associated with wet earwax is linked with an increased risk of hidradenitis suppurativa .[ref] Hidradenitis suppurativa is a painful skin condition causing pus-filled lumps under the skin, usually in the underarms, buttocks, or groin areas

Critically, the oxidative breakdown of integrated PUFA-PLs affects membrane integrity whereas isolated olyunsaturated fatty acid hydroperoxides (PUFA-OOH) have no membrane-disrupting properties (Liu et al., 2024)

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