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Preclinically, FMT from ICI-responding patients reprograms the gut microbiota of germ-free or ATB-treated mice not only by expanding beneficial taxa (e.g., Bacteroides thetaiotaomicron , Faecalibacterium prausnitzii ) but also by restoring critical metabolites: SCFAs (butyrate, acetate) that enhance CD8 + T cell infiltration into the TME and suppress Treg differentiation, and Trp derivatives (IPA) that activate the AhR to boost DC maturation (261, 290, 291)

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This work was supported by the Program of Science and Technology Department of Sichuan Province (grant nos

The peptide promotes tight junction integrity in intestinal epithelial cells, the same tight junction proteins that are compromised in eczema skin