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Beyond the traditional M1-M2 paradigm, current transcriptomic analyses reveal greater TAM diversity with seven main subtypes: interferon-primed TAMs (IFN-TAMs), immune regulatory TAMs (Reg-TAMs), inflammatory cytokine-enriched TAMs (Inflam-TAMs), lipid-associated TAMs (LA-TAMs), proangiogenic TAMs (Angio-TAMs), RTM-like TAMs (RTM-TAMs), and proliferating TAMs (Prolif-TAMs) ( Figure 6 ) (94)

Sulforaphane was the first identified and most potent naturally occurring NRF2 activator found in cruciferous vegetables such as broccoli, cauliflower, and Brussel sprouts (Zhang et al., 1992

36 Cohort studies have established that iron deficiency is related to reduced muscle mass in individual community residents and impairs the proliferation of myoblasts