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Importantly, elevated glycated hemoglobin (HbA1c) levels, reflecting long-term poor glycemic control, have emerged as a reliable biomarker predicting poorer response to immunotherapy, suggesting that rigorous management of glucose metabolism is critical to optimizing therapeutic outcomes in these patients [115,116,117]

[PubMed] [Google Scholar] Meyer AJ, Dreyer A, Ugalde JM, Feitosa-Araujo E, Dietz KJ, Schwarzlnder M

These compounds activate the Nrf2 pathway, a cellular signaling system that upregulates expression of genes involved in antioxidant production including glutathione synthesis enzymes