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J Pharmacol Exp Ther 370(2):337349

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These effects peak during the first 48 weeks at each dose increase and typically resolve as receptor density adjusts slow titration schedules mitigate severity without compromising efficacy endpoints

Estimation of brain apoptotic markers The apoptosis in brain was assessed in terms of apoptotic markers such as Bax, Bcl-2 and Caspase3 24 by using an ELISA assay