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M.FischbachS.et al (2018)

Furthermore, compared to directly targeting LDHA, metabolic interventions aimed at upstream glycolytic regulators may elicit broader biological effects and potential unpredictability ( The aforementioned upstream intervention strategies targeting lactate production and transport offer the advantage of simultaneously reversing microenvironmental acidification and inhibiting lactylation modifications, thereby achieving dual antitumor effects

Polymers 11, 1449

A harming role for macrophages is suggested by the observation of increased expression of VAV1, a protein playing a role in T- and B-cell development and activation, by liver Kupffer cells in AIH patients, as well as by higher serum levels of CD163, produced by activated macrophages, which normalize during disease remission [102, 103]