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If left unaddressed, a deficiency can result in severe complications, including irreversible nerve damage or memory impairment, making early diagnosis and ongoing treatment essential

Thyroid disorders in mild iodine deficiency

Additionally, under extreme reactive oxygen species (ROS) accumulation, cancer cells rewire the Gln metabolic pathway to maintain redox homeostasis via NADPH production through glutaminolysis 9

However, the specific impact of disrupting this pathway via myeloid-specific HIF-1 deletion on macrophage function and the overall bone regeneration process remains an open and critical question