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In Escherichia coli, the lacZ gene is the structural gene for -galactosidase and can be used as part of the lac manipulator of the inducible system

Service providers report that youth were often aware of the mandatory reporting requirements of shelters and therefore many avoided contact with these programs and/or figured out ways to manipulate the system by staying only until the time period for mandatory reporting elapsed and then proceeding to another shelter, which is commonly known as shelter hopping

The ALOX12 R261Q mutation located in the LOX enzymatic activity domain was reported to increase urinary 12-HETE excretion and was associated with essential hypertension, 184 suggesting an enzymatic activity-dependent mechanism underlying the regulatory effect of ALOX12 on hypertension