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Acetyl-L-carnitine seems to be more effective than a drug called tamoxifen for reducing pain and slowing worsening of the condition

2.6 Carnitine monooxygenase activity assays The standard L-carnitine depletion assay was performed as detailed under (Piskol et al., 2022) in the presence 2 mM L-carnitine and 2 mM NADH

However, it has also been reported that increased or excess levels of Akkermansia in PD patients, where it is reported to be correlated with increased inflammation 101