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Both activate AMPK, but through distinct mechanisms: metformin inhibits complex I of the mitochondrial electron transport chain, raising the cellular AMP:ATP ratio and thereby activating AMPK indirectly

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Approach Standard cycle Duration 4 weeks Review Point Week 4 Typical Context General research planning context

Middle School Improvements: Renovation and modernization projects at Alston Middle School, Dubose Middle School, and Gregg Middle School Districtwide Infrastructure Investments: Roof replacements and repairs across multiple campuses HVAC system upgrades, along with new equipment and classroom furniture Replacement of school buses, including general and special education fleets Playground construction and upgrades Flooring and lighting improvements Ongoing Capital Maintenance & Technology Continued investment in building maintenance and technology upgrades to ensure schools remain safe, efficient, and equipped for modern instruction.