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3 The simplest definition of IC/BPS as provided by the American Urological Association (AUA) is an unpleasant sensation (pain, pressure, or discomfort) perceived to be related to the urinary bladder, associated with lower urinary tract symptoms of more than six weeks duration, in the absence of infection or other identifiable causes. 4 In 1988, the National Institute of Diabetes and Digestion and Kidney Diseases (NIDDK) developed rigorous diagnostic criteria for research on IC

10.1016/j.neuron.2014.11.018 275 LiangS.ZhaoL.NiP.WangQ.GuoW.XuY.et al

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In vivo experiments demonstrated that MnHARis exhibits excellent long-term stability and good biocompatibility