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GBM cells, regardless of their cellular origin or genetic heterogeneity, are dependent on fermentation for survival due to abnormalities in mitochondrial structure and function

Furthermore, peripheral blood mesenchymal stem cells have been shown to exert antioxidant and anti-apoptotic effects in vitiligo cell models via the paracrine activation of IL-10 on the PI3K/Akt signaling pathway [139]

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However, antigen sampling of luminal microbes is necessary for immunological development, bacterial clearance and the production of IgA, the latter of which is important in restricting microbial adhesion to the mucosal layer and coating commensal species to limit their interaction with immune system (Johansen et al