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The second-generation MUC28z CAR T cells derived from scFv of TAB004 significantly lysed TNBC tumor cells despite with high surface expression of programmed death 1 (PD1), and this activity strongly correlated with level of surface expression of tMUC1[18]

Guo C, Sun L, Chen X, Zhang D

Glutathione Competitively inhibits melanin synthesis in the reaction of tyrosinase and L-DOPA by interrupting L-DOPA's ability to bind to tyrosinase during melanin synthesis

However, there are many more studies that need to be carried out, and the description of ferroptosisa relatively unexplored cancer cell death mechanism that is inhibited by glutathione-dependent GPX4reinforces the importance of cysteine in cancer and points to new perspectives regarding the ways whereby cysteine import and synthesis and glutathione synthesis can be efficiently targeted in order to trigger cell death in cancer