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& Annapragada, A

CD3, PHOX2B and HLA-ABC antibodies were used at 1:100, 1:500 and 1:1,200 dilutions, respectively

Conclusion: Here we report a novel function of portal fibroblasts as drivers of cholestatic fibrosis, ductular reaction, inflammation, hepatocyte senescence, and HCC in aged mice, demonstrating the key role of the tumor microenvironment