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Various standardized scales, such as the Numerical Rating Scale, Dermatology Life Quality Index, and 5D Itch Scale, serve as objective metrics in clinical settings, evaluating diverse facets of itching encompassing its intensity, distribution, and associated conditions like anxiety, depression, and insomnia, along with overall quality of life (22)

In anaerobic environments, it produces nitric oxide (NO), which inhibits cytochrome c oxidase and reduces ATP production in non-replicating Mtb cells (Pstragowski, Zbrzezna, and Bujalska-Zadrozny, 2017

found that in the CIRI model, increased LDHA-mediated H3K18 lactylation modification promotes the transcription of HMGB1

The abnormal distribution and content of iron in the body will impact normal physiological activities [3, 18]