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8.1.2 Before initiating second-line immunosuppressive therapy, it is essential to exclude sub-optimal dosing, non-adherence, alternative etiologies, co-morbidities and autoimmune sclerosing cholangitis/overlap syndrome (LOE 5, Strong recommendation)

27, Nikolai Rimsky-Korsakov (1844-1908)

both scores subsequently reached 0 by day 60, indicating remission

Endocannabinoid degradation inhibition improves neurobehavioral function, blood-brain barrier integrity, and neuroinflammation following mild traumatic brain injury