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This is the most significant pathological feature of PD, suggesting that seeking dopaminergic neuronal protective strategies may be the most important means to treat PD

J.|Manfredsson, F.|Sortwell, C

Cells that take up the target molecule of DNA (cell surface expression of membrane- associated DNA binding domains) will express the factor and have increased specific affinity for target DNA that remains extracellular, while cells that did not take up DNA will be at a competitive disadvantage as they will not bear the cell surface target DNA- specific binding domain, which is required for specifically mediated DNA uptake The method uses cell surface expression of membrane-associated DNA binding domains of, for example, transcription factors, that are encoded in the target DNA sequence, which also includes the cognate recognition sequence for the binding domain

These discrepancies may result from population stratifications, explicitly, socio-economic status