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The detrimental effects of B12 deficiencysuch as hyperhomocysteinemia and impaired methylationare well-established and can negatively impact oocyte quality and embryo viability [19, 20], which is consistent with the lower pregnancy rates we observed at low B12 levels

Notably, all patients had previously been treated with pentosan polysulfate, which is currently the only FDA approved treatment for interstitial cystitis, and had not responded