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Nicotinic acid was the first hypolipidemic agent shown to decrease the incidence of secondary myocardial infarction (MI) and reduce total mortality in MI patients

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Concurrently, it functions as an essential cofactor for prolyl hydroxylase and lysyl hydroxylase, enzymes critical for collagen biosynthesis (Nassar et al., 2025)

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Crystallization and preliminary X-ray crystallographic studies of dehydroascorbate reductase (DHAR) from Oryza sativa L

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These authors make the point that genetic effects often appear to be greater in males, perhaps related to their tendency to higher UA concentrations

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