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Vitamin B 12 and nucleic acid metabolism The figure shows pathways of folate and vitamin B 12 metabolism of nucleic acid synthesis and methylation reactions

Even low-normal B12 levels can result in deficiency symptoms

Moreover, 3 viral vectors (a type of nonreplicable vector and two types of replicable vectors) + antigen-presenting cells and a vaccine based on the bacterial antigen-spore expression vector are also approved for clinical trials ( COVID-19 protein subunit vaccine Protein subunit vaccines are based on systemically expressed viral proteins or peptides using various cell-expressing systems, such as bacteria, yeasts, insects, and mammalian cells (such as human embryonic kidney cells)

WAC is generally not used when ASP is unavailable beyond those circumstances