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In the future, multi-organ protective intervention strategies need to be developed by targeting the TLR4 pathway, clearing circulating LPS, and regulating the microbiota-immune axis to contain the uncontrolled inflammation and organ failure driven by microbial products in sepsis

The combined effects lead to improved glycemic control in people with type 2 diabetes and substantial weight loss in appropriate patients

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To view a copy of this licence, visit About this article Cite this article Cui, Z., Esposito, A., Napolitano, G