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were the first to hypothesize that reducing NLRP3 may extend HS by delaying multiple age-related degenerative changes in the periphery and the brain

doi: 10.1017/S0033291718000454

It is synthesized from glycine and succinylcoenzyme A, which condense to form 5-aminolevulinate (5-ALA)

These proteins are essential for regulating the paracellular transport thereby controlling the selective passage of ions, solutes, and water between intestinal epithelial cells (Van Itallie and Anderson, 2014), maintaining cell polarity and facilitating cell differentiation and proliferation (Farkas et al., 2012)