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In this same pathway of sulfur amino acids, HCY can be metabolized producing glutathione (GSH) ( Figure 1 ) ( IL1B and CCL3 also play a central role in the pathophysiology of COVID-19 ( Figure 1 The hypothesis of this study is that, during the advanced phase of COVID-19, characterized by hyperinflammation (cytokine storm), supplemental vitamin B12 would increase the flow of the sulfur amino acid pathway, favoring the production of SAM and the antioxidant GSH

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doi: 10.3389/fphar.2025.1546836 Received 17 December 2024 Accepted 10 March 2025 Published 15 April 2025 Volume 16 - 2025 Edited by Chong Xu, China Pharmaceutical University, China Reviewed by Yonghu Sun, Shandong Provincial Hospital of Dermatology, China Chengfeng Zhang, Fudan University, China Updates Copyright 2025 Paganelli, Papaccio, Picardo and Bellei