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For example, taking very high doses of vitamin B6 can lead to potentially irreversible nerve damage over time, while taking large amounts of niacin typically in excess of 2 grams per day can cause liver damage ( Fat-soluble vitamins Unlike water-soluble vitamins, fat-soluble vitamins do not dissolve in water and are easily stored in your bodys tissues ( There are four fat-soluble vitamins: Vitamin A Vitamin D Vitamin E Vitamin K Given that fat-soluble vitamins can accumulate in the body, these nutrients are more likely to lead to toxicity than water-soluble vitamins

doi: 10.3389/fcell.2016.00072 24 Enlimomab Acute Stroke Trial Investigators (2001)

Tomin T, Bordag N, Zgner E, Al-Baghdadi A, Schinagl M, Birner-Gruenberger R, et al

Several studies reported that SP displayed protective effects in rats liver and kidney against toxicities through upregulation of the SIRT1 expression 28,29