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Heat-evoked activation of the ion channel, TRPV4

Strikingly, expression of the HIF target genes Egln3, Pdk1, Mct4, and Glut1 was reduced more than twofold in nNPCs compared to eNPCs, suggesting that the switch to neurogenesis in the cortex is linked to a downregulation of HIF target genes (Fig 5U)