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Meta-analytical evidence has demonstrated limited benefit over placebo in reducing OA pain, particularly in knee and hip OA, and its use is increasingly de-emphasized in clinical guidelines ( TABLE 2 Pharmacological therapies for osteoarthritis: clinical use, evidence, and limitations

the binding of Rac protein to these elements completes activation [19]

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73 , 13451349 (1991) McCloskey, J.A., Nishimura, S.: Modified nucleosides in transfer-RNA