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Dong H, Wang Y, Zhang X, et al

Parrow NL, Fleming RE, Minnick MF

Available evidence suggests that ferroptosis integrates multiple upstream damage signals, including pathogenic bacterial infection, iron overload, and oxidative stress, and may exacerbate tissue destruction and inflammation amplification through positive feedback loops

Based on strong relationship between glutamine metabolism and biological features of ATC, we hypothesized ATC are vulnerable to glutaminolysis inhibition