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[24] Patients with advanced liver disease, severe kidney disease, hypertriglyceridemia, or cardiovascular conditions should consult their healthcare provider before any alcohol consumption, as these conditions may be worsened by alcohol independently of tirzepatide considerations

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To address these barriers, advanced drug delivery systems (e.g., nanoformulations, liposomal carriers, prodrugs) are being explored to enhance bioavailability and targeted drug delivery to the brain