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Blood 128(3):440448 Arnold DE, Seif AE, Jyonouchi S, Sullivan KE, Bunin NJ, Heimall JR (2019) Allogeneic hematopoietic stem cell transplantation in adolescent patients with chronic granulomatous disease

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However, these reactions invariably result in the generation of reactive oxygen species (ROS) compounds that are unstable by having final layer of electrons unpaired and that, in trying to stabilize itself sequester electrons from other biomolecules, making them also destabilizes and, therefore, is no longer able to perform their duties properly, thus altering the homeostasis and, ultimately, causing cell death