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IL-6 inhibition Tocilizumab (TCZ) is a humanized monoclonal antibody that targets the IL-6 receptor, which is found on cell surfaces and in circulation

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Harland DP, Popescu C, Richena M et al (2022) The susceptibility of disulfide bonds to modification in keratin fibers undergoing tensile stress

Overexpression of miR-506 in cholangiocytes leads to multiple PBC-like features, including impaired cell proliferation and adhesion, sensitization to bile acid-induced apoptosis, impaired energy metabolism, PDC-E2 overexpression and mislocation into the plasma membrane, and immune activation