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In two studies assessing patients with NASH, metformin use was associated with reduced all-cause mortality or transplantation (HR: 0.42 95% CI 0.33-0.54, total of 505 patients, figure 3)

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While nephron hypertrophy, which refers to the enlargement of non-sclerosed glomeruli (NSG) volume and tubular area alongside a reduction in glomerular density, shows a relatively weak correlation with age, it exhibits a stronger association with specific coexisting conditions that are prevalent among older populations, such as obesity, diabetes, and hyperuricemia ( In addition to that, the quantity of nephrons declines as individuals age (Shankland et al., 2023)