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(1974) indicated that physical properties of this protein evaluated in 1967 by a set of biophysical techniques, such as gel-filtration chromatography, viscometry, and optical rotatory dispersion (ORD) have led to the conclusion that chromogranin A has a conformation approaching that of a random-coil polypeptide (Smith and Winkler, 1967)

Davis, E

Another study with CuCl 2 treated Hep G2 cell line demonstrated that mitochondrial toxicity is an intermediate-level event associated with copper toxicity to Hep G2 cells while lysosomal damage is the early event and plasma damage a late feature associated with copper toxicity 34