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During the development of osteoarthritis, the synovium undergoes interstitial vascularization, fibrosis and hyperplasia (167), and macrophages and fibroblasts in the synovium can release proinflammatory cytokines, etc., which cause synovitis and cartilage degeneration

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Clinical Update 4/20/2016 Diabetes Cured With Low Cal Diet A recent study found that type 2 diabetes was reversed in 40% of people who followed an 8-week, very low calorie diet consisting mainly of a diet shake

It may also affect neurotransmitters such as dopamine and serotonin , raising interest in neurological applications