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Subsequently, H 2 O 2 formation as a by-product of epithelial growth factor (EGF) induces the Akt (Protein kinase) and P70S6K1 (Ribosomal protein S6 kinase beta-1) signalling that are involve in protein synthesis during human ovarian cancer cells

The human GST multi-gene superfamily is encoding for various ubiquitous cytosolic or soluble, mitochondrial and microsomal as well as peroxisomal homo- and heterodimeric transferases ( S -conjugation generates a less or non-toxic product with improved water solubility, favoring the exportation out of the cell and thereby contributing to DNA damage prevention and protection of the cellular integrity ( Regardless the importance of GST activity for cellular vitality and health, the GST gene cluster is a hotspot for DNA sequence mutations that leads to the expression of active but functionally different GST variant proteins

Kwon and Ciechanover, 2017)