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qPCR results showed that toxin treatment suppressed the expression levels of PPAR downstream genes, SOD and CAT , by reducing H3K18la levels (Supplementary Fig

Schapira, 2010)

3.1.4 Carotenoids (-carotene, lutein, etc.) Carotenoids are a series of potent antioxidants, primarily involving-carotene, lutein, and others, with the ability to grab and neutralize oxygen free radicals like singlet oxygen ( in vivo through quenching singlet oxygen (1O2) and other reactive oxygen species (ROS) by physical and chemical reactions ( To be specific, carotenoids can efficiently neutralize parlous free radicals by physical quenching of singlet oxygen (1O2) and other ROS, which is importaant for protecting the integrity of cell membranes and organelle functions, particularly under conditions of oxidative stress ( Hence, carotenoids, with their potential antioxidant features, is of great importance in keeping the structure and function of periodontal tissues from oxidative damage, emphasizing their possible application in keeping oral health

The targeting of Prx5 to mitochondria is highly conserved among species (Van der Eecken et al., 2011), and it has been associated with the protection of mtDNA from oxidative attacks (Banmeyer et al., 2005)