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1454-C AN EFFECTIVE STRATEGY TO REDUCE HBsAg LEVEL WITHOUT DIRECT INHIBITION OF INTRACELLULAR HBsAg SYNTHESIS IN HBV INFECTED HUMANIZED MICE Bai-Hua Zhang 1 , Yong-Yuan Zhang 1 , Yuanping Zhou 2 , Ben Tempel 1 , Todd Parsley 3 and Fabien Zoulim 4 , (1)Hbvtech, (2)Nanfang Hospital, (3)Noble Life Sciences, (4)Hpatologie Unit, Hospices Civils De Lyon, Lyon University, Inserm Background: The current strategy to reduce serum HBsAg is to inhibit cellular HBsAg synthesis using siRNA/ASO drugs that show an average 100,000mIU/ml in all treated mice during the experiment period