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Analytical Method Development and Validation of Content of D-Carnitine in Levocarnitine Using High-Performance Liquid Chromatography 1

Moreover, a percentage of patients ranging between 7 and 25%, depending on different dosage, experience adverse events upon PDE5i treatment [59, 60], sometimes manifesting as of moderate or severe entity, the most frequent of which comprise flushing, headache, dyspepsia, back pain, myalgia, dizziness, and rhinitis [10], although discontinuation rates owing to adverse events of PDE5i is generally relatively low, and comprised between 3 and 5% of patients [61]

doi:10.1589/jpts.34.503

This organism was chosen as production host because its natural interactions with L-carnitine are already well understood: It uses L-carnitine as compatible solute under hyperosmotic stress conditions and as terminal electron acceptor in anaerobic respiration yielding -BB (Seim et al., 1980