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.It will be readily apparent to those skilled in the art that other suitable modifications and adaptations to the methods and applications described herein can be performed without departing from the scope of any embodiment

The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation

An equal volume of vehicle was administrated to control mice

Additionally, GSEA analysis of iSPN + mut at 3 months revealed a significant reduction in the expression of genes associated with the first stage of the cellular respiration process glycolysis and the tricarboxylic acid cycle, followed by a further decrease at 8 months (Supplementary Table 1b,c,e,f)