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Nat Rev Drug Discov (2020) 20:10124

Unlike earlier GH secretagogues, ipamorelin exhibits high selectivity, minimal activity at other hormonal axes (ACTH, cortisol, or prolactin), and potent GH release in both animals and humans

doi: 10.1073/pnas.1424563112 61 DavisJ

These findings challenge the notion that LS pathology uniquely involves neuronal degeneration and redox imbalance, suggesting instead an impairment of neuronal morphogenesis due to NPC dysfunction