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In PCOS granulosa cells, elevated phosphorylation of the pro-apoptotic protein BAX, coupled with suppressed phosphorylation of the anti-apoptotic protein BCL-2, enhances mitochondrial pathway apoptosis, accelerating follicular atresia ( 3.6 Chronic low-grade inflammation Chronic low-grade inflammation have been identified as a central component in the pathogenesis of PCOS, rather than mere accompanying phenomena

One small mouse study in a stress-induced alopecia model found that oral curcumin partially improved markers of anagen and hair density but did not restore them to normal, and there are no human clinical trials of curcumin alone for hair loss, either oral or topical

On the contrary, chemotherapeutic drugs have the potential to markedly increase ROS levels, which might result in oxidative stress if ROS generation overwhelms the antioxidant defence of the cell (Bhattacharya 2015)

Amylin restrains this pathological postprandial glucagon secretion, and it does so most powerfully in the fed state, reducing inappropriate hepatic glucose output