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WangYZhouXZhaoDWangXGurleyECLiuRet alBerberine inhibits free fatty acid and LPS-induced inflammation via modulating ER stress response in macrophages and hepatocytes

NRF2 protein is unstable under basal conditions, being ubiquitinated by an E3 ubiquitin ligase kelch-like ECH-associated protein-1 (KEAP1) and subsequently undergoing rapid degradation through the proteasome pathway